The purpose of this study was to enhance the dissolution pattern of the practically water insoluble antihypertensive drug, olmesartan medoxomil through its formulation into liquisolid tablets. A mathematical model was used to formulate many liquisolid powder systems using propylene glycol as a non-volatile water miscible liquid vehicle. The liquid loading factors of the vehicle were used to calculate the optimum quantities of carrier (Avicel PH 102) and coating materials (aerosil 200) needed to prepare acceptably flowing and compactible powder mixtures. Different excipient (R) ratios were used (20, 30, 40 and 50). The liquisolid tablets were evaluated for weight variation, percent friability, hardness, content uniformity, disintegration time and in-vitro drug release profile. Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FT-IR) were used for the assessment of the physicochemical properties of drug in the liquisolid tablets. The enhanced dissolution rate due to the increased wetting properties and the large available surface areas for dissolution were obtained in case of the liquisolid tablets. The selected optimal formulation (LS3) released 74.74% of its content during the first 5 min compared to 9.18% of the plain drug and 40.54% of directly compressible tablet. In conclusion, the dissolution rate of olmesartan medoxomil can be enhanced to a great extent by liquisolid technique.
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